讲座题目：Microfluidics-enabled cancer diagnostics 主讲人：孙佳姝 研究员 主持人：田阳 教授 开始时间：2019-07-30 15:00:00 讲座地址：闵行教师之家宾馆三楼报告厅 主办单位：华东师范大学化学与分子工程学院
报告人简介： 孙佳姝，博士，研究员，博士生导师。 2006 年获得北京理工大学材料科学与工程学士学位， 2010 年获得美国范德堡大学机械工程博士学位。 2011 年加入国家纳米科学中心， 2016 年入选北京市科技新星计划，中国科学院青年创新促进会。主要从事新型微纳流控器件的研究，在功能纳米材料精准合成、以及纳米药物筛选平台构建等方面，取得了一系列原创性成果。近年来已发表SCI 学术论文60余篇，其中通讯或第一作者论文发表在Chem. Soc. Rev., Nature Commun., Angew. Chem. Int. Ed., Adv. Mater., Nano Lett., ACS Nano等国际高水平期刊，并有10余项微流控相关发明专利授权。作为负责人获得面上基金资助，作为子课题负责人获得国家高技术研究发展计划（863计划），中国科学院战略性先导科技专项资助；作为研究骨干参与国家重大科学仪器设备开发专项等。 报告内容： Noninvasive, rapid, and low-cost methods for screening and classification of early stage cancers are of great significance. Despite the promise of liquid biopsy in early cancer diagnostics, significant efforts are required to overcome the technological challenges in isolation, detection, and interpretation of heterogeneous circulating biomarkers. Here we develop a one-step thermophoretic aptasensor (TAS) for early stage cancer detection and classification, as well as monitoring of cancer recurrence through profiling the surface proteins of extracellular vesicles (EVs) in less than 1 μL serum samples. In a pilot study (n = 172), this EV assay achieves 95% sensitivity and 100% specificity for detection of Stage I cancers, with an overall accuracy of 68% for discriminating six cancer types (Stage I to IV). For prostate cancer (n = 60), EV signature is superior in its ability to discriminate prostate cancer and benign disease than serum PSA, and acts as a promising biomarker to monitor biochemical recurrence after radical prostatectomy. This TAS method demonstrates a huge translational potential for EVs-based cancer diagnostics. |
