讲座题目：Advanced In Vivo Fluorescence Imaging: Seeing is Believing 主讲人：王强斌 研究员 主持人：田阳 教授 开始时间：2019-06-14 10:00:00 讲座地址：闵行校区实验D楼207报告厅 主办单位：华东师范大学化学与分子工程学院
报告人简介： 王强斌，中科院“百人计划”研究员，博士生导师，中国科学院纳米-生物界面重点实验室主任，国家杰出青年基金获得者和万人计划科教领军人才，英国皇家化学会会士，中国化学会理事，中国化学会纳米化学分会副秘书长，中国生物材料学会影像材料与技术分会副主任委员。 主要研究方向：功能纳米材料、纳米生物技术、近红外II区荧光技术及其转化医学等 主持国家级项目10余项，发表研究论文105篇，申请专利28项，授权13项。2017年获江苏省科学技术进步一等奖。
报告内容： Fluorescence imaging in the second near-infrared window (NIR-II, 1.0~1.7 μm) is appealing in in vivo imaging due to negligible tissue absorbance and tissue scattering, as well as minimal autofluorescence in this region, affording maximal penetration depth for deep tissue imaging with high feature fidelity. Herein, for the first time, we reported a new type of NIR-II QDs-Ag2S QDs and executed a series of in vivo imaging studies with Ag2S QDs. The results show that, by using Ag2S QDs, the tissue penetration length can reach 1.5 cm, and the spatial and temporal resolution of the in vivo imaging can down to 25 µm and 30 ms, respectively, which are improved several to dozens of times in comparison with those using conventional fluorescence nanoprobes in the visible and the first near-infrared window (650-900 nm), offering in situ, real-time visualization of the biological events in vivo. With the advanced NIR-II fluorescence of Ag2S QDs, high signal to noise ratio imaging of tumor growth and metastasis, imaging-guided drug delivery and therapeutics, imaging-guided precision surgery, and stem cell tracking and regeneration in vivo, etc, have been achieved. |
