讲座题目：The total synthesis story of complex taxane
主讲人：Tanja Gaich 教授
主持人：高栓虎 教授
开始时间：2024-08-15 10:00
讲座地址：普陀校区化学馆A205报告厅
主办单位：化学与分子工程学院
报告人简介：
Since 2015: Full Professor of Organic Chemistry (chair), University of Konstanz, Germany 2010–2015: Independent group leader as VCI fellow and as Sofja Kovalevskaja fellow funded by the Alexander v. Humboldt Foundation at the University of Hannover. 2009–2010: Erwin-Schrödinger Postdoctoral fellow at the Scripps Research Institute La Jolla California Mentor 2005–2009: PhD, University of Vienna, Austria
报告内容：
Taxus, a genus of slow-growing evergreen shrubs known as yews, produces unique diterpenes called taxanes, found only in Taxus and Austrotaxus spicata. Traditionally, yew extracts were used in folk medicine for various treatments. In the 1950s, the National Cancer Institute began screening plant extracts for tumor models. In 1964, Wall and Wani isolated taxol (paclitaxel) from yew bark, with its full clinical potential recognized in 1974. Taxol revolutionized cancer treatment by promoting irreversible tubulin assembly into microtubules. Scarcity led to extensive synthetic efforts, culminating in total syntheses in 1994 and solving supply issues via semi-synthesis, but production remains challenging. However, the bioactivity of complex taxanes, or cyclotaxanes, is significantly underexplored despite their potential to reverse multidrug resistance and enhance anti-cancer effects. Certain complex taxanes have shown remarkable multidrug-resistance-reversing activity and enhanced the anti-cancer therapeutic effect by increasing the cellular accumulation of vincristine (VCR) in P388/VCR-bearing mice and tumor cells. However, further research into complex taxanes is hindered by low natural availability, non-sustainable resources, and the lack of efficient synthetic routes. Here we will discuss the story of our synthesis of complex taxane family natural product.
