讲座题目：Total synthesis of the antibiotic RiPP natural products Darobactin and Dynobactin
主讲人：Fabian Schneider 研究员
主持人：高栓虎 教授
开始时间：2024-08-15 09:00
讲座地址：普陀校区化学馆A205报告厅
主办单位：化学与分子工程学院
报告人简介：
From 12/2021 Postdoctoral Fellow, Scripps Research (Prof. Dr. P. S. Baran)； 2017 – 2021 PhD Studies University of Konstanz (Prof. Dr. T. Gaich)； 2015 – 2017 University of Konstanz Master of Science (M.Sc. Chemistry)； 2011 – 2015 University of Konstanz Bachelor of Science (B.Sc. Chemistry)
报告内容：
Darobactin and Dynobactin are recently discovered RiPP (ribosomaly synthesized, post-translationally modified peptide) natural products that show promising potent antibacterial properties against Gram-negative pathogens in combination as well as low toxicity against intestinal gut bacteria and human cell lines. Adding further intrigue and promise to this class of antibiotics is it’s apparent ability to evade bacterial resistance through mutation. Both natural products demonstrated a novel mechanism of action targeting BamA, a bacterial insertase within the β-barrel assembly machinery (BAM) complex that facilitates folding and insertion of outer membrane proteins in Gram-negative bacteria. Testimony to their nature as RiPP natural products, Darobactin and Dynobactin exhibit a number of unusual structural features, comprising b-branched amino acids with additional C-C and C-N bond connectivities resulting in a strained system of fused (Darobactin) or linked (Dynobactin) macrocycles. Solutions towards these synthetic challenges will be discussed, leading up to the successful total synthesis of Darobactin and Dynobactin.
