讲座题目：Should I stay or should I go? Frontocortical mechanisms of learning under uncertainty 主讲人：Alicia Izquierdo 教授 主持人：郭思齐 副教授 开始时间：2019-05-14 13:30:00 讲座地址：中北校区地理楼385 主办单位：心理与认知科学学院、上海市脑功能基因组学重点实验室
报告人简介： Dr. Izquierdo received a B.S. in Biology and Psychology from Emory University, and a Ph.D. in Cognitive Neuroscience through the Graduate Partnership Program between the National Institutes of Health and The George Washington University. After completing her doctoral work at the National Institute of Mental Health, she spent two years as a postdoctoral fellow at the National Institute on Alcohol Abuse and Alcoholism. Dr. Izquierdo is active in a number of national and international organizations and initiatives that promote diversity and inclusion in STEM. She also devotes significant energy to mentoring, recognized by the Department's J. Arthur Woodward Graduate Mentor Award for 2018. 报告内容： Orbitofrontal cortex (OFC) and Anterior cingulate cortex (ACC) have been assigned various overlapping roles ranging from learning and responding to reward, signaling value and uncertainty, and supporting economic decisions, to name a few. Using a combination of novel behavioral paradigms, DREADDs, calcium imaging, and computational modeling, our lab has sought better resolution of these diverse frontocortical processes in rat. In this talk I will present data comparing OFC and ACC in flexible reinforcement learning under uncertainty. Our results suggest highly overlapping, less specialized, roles for ACC and OFC in learning under uncertainty that point toward a shared role of both structures in keeping track of outcomes over time, and with repeated experience. Our more recent data will be discussed with an eye toward similarities in ACC and OFC function across cognitive domains, from perceptual to value- based decisions. Collectively these findings may have implications for how we view frontocortical contributions to reinforcement learning and value-based decision making across rodent and primate species.
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