讲座题目：Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
主讲人：李子林 教授
主持人：於州 教授
开始时间：2024-06-21 15:00
讲座地址：普陀校区理科大楼A1114
主办单位：统计学院
报告人简介：
李子林，东北师范大学数学与统计学院教授。历任印第安纳大学医学院生物统计与健康数据科学系助理教授，哈佛大学生物统计系博士后、副研究员和研究员。本科与博士毕业于清华大学数学科学系，师从美国国家科学院与医学院两院院士林希虹院士。2023年当选为国际统计学会（International Statistical Institute）推选会员（Elected Member），获阿里巴巴达摩院青橙奖“最具潜力奖”。主要研究方向为高维数据中的统计方法理论和统计遗传学。相关研究成果以第一作者或通讯作者在Nature Methods、Nature Genetics、JASA等国际学术期刊发表。
报告内容：
Large-scale whole genome/exome sequencing (WGS/WES) studies have enabled the analysis of rare variants (RVs) associated with complex human traits. Existing RV meta-analysis approaches are not scalable when applied to WGS/WES data. We propose MetaSTAAR, a powerful and resource-efficient RV meta-analysis framework, for large-scale WGS association studies. MetaSTAAR accounts for population structure and relatedness for both continuous and dichotomous traits. By storing LD information of RVs in a new sparse matrix format, the proposed framework is highly storage efficient and computationally scalable for analyzing large-scale WGS/WES data without information loss. Furthermore, MetaSTAAR dynamically incorporates multiple functional annotations to empower RV association analysis, and enables conditional analyses to identify RV-set signals independent of nearby common variants. We applied MetaSTAAR to identify RV-sets associated with four quantitative lipid traits in 30,138 related samples from the NHLBI TOPMed Program Freeze 5 data, consisting of 14 ancestrally diverse studies and 255 million variants in total, as well as the UK Biobank WES data of ~200,000 related samples. MetaSTAAR requires at least 100 times storage smaller and computationally faster than existing methods. Compared to the joint analysis of pooled individual-level data using STAAR, the P-values from MetaSTAAR and STAAR are highly concordant, with correlation > 0.99 among significant RV-sets. Additionally, MetaSTAAR identified and replicated several conditionally significant RV associations with blood lipids levels.
